Genomic Research

Genomic research is the most innovative methodology in medical research. Normal human genome, that is the genetic anatomy of human genes, was studies and mapped several years ago. By present estimates, humans have approximately 20,000-25,000 genes. This research continues full speed to map out the genes within cancer tissue. Several cancers have been studied in this manner.

The Cancer Genome Atlas, a large and federally funded project aims eventually to catalog all major cancer-causing genomic alterations; performing a range of studies, including DNA copy number, gene expression, DNA methylation, and many other analyses of the genes of cancer tissues. These studies have proven that within each cancer, there are several genes that are over-activated and others that are suppressed. Learning functions of these genes, and how they interplay with the growth of cancer cells has allowed development of treatment strategies which are already helping cancer patients.

KRF is committed to apply the same technology to keloid and broaden our understanding of genetic makeup of this disease; and hopefully find targets that can be treated with existing or future medicines. Our planned tissue bank for keloids will provide the material needed for this research.

Accelerated methods for studying the three-dimensional structure of proteins, including those proteins that serve as targets for drugs against disease, are likely to have profound effects on approaches to treatment of keloid.

We need your support to make this ideal to become a reality.


    2nd International Keloid Symposium:

    (Januar 18, 2018) KRF is proudly announcing that the 2nd will be held on June 7-8, 2018 in Rome, Italy. Click on the image below to be directed to the symposium website.

    Notice of 501 (C)(3) Status:

    (February 1, 2017) Keloid Research Foundation has been determined by the US Internal Revenue Service (IRS) to be exempt from federal income tax under Internal Revenue Code (IRC) Section 501(C)(3). Donors can deduct contributions they make to KRF under IRC Section 170. Click here to view the 501(C)(3) Exemption Document.

    Journal of Keloid Research:

    (December 3, 2016)KRF is proud to announce establishment of Keloid Research, an open access scientific publication of the Keloid Research Foundation. Until now, keloid manuscripts have been published in a variety of journals. Our goal is to create a centralized publishing platform for all researchers who are passionate about this disorder, so that relevant clinical and laboratory research can be published in one place and under one umbrella. The journal is aiming to provide an international forum for the publication of original work, describing basic science, translational and clinical investigations in keloid disorder.

    Keloid Staging System:

    (August 19, 2016) In his most recent publication, "Neck Keloids: evaluation of risk factors and recommendation for keloid staging system" Dr. Tirgan has designed a staging system that allows for proper categorization and grouping of keloid patients into various stages.

    To assess each keloid patient properly, to better understand the natural history of this disorder, and to be able to compare future keloid study results among various patients groups, we clearly need a staging system that can allow us to describe the severity keloid disorder based on the size, location and/or extent of the keloidal lesions; as well as history of surgery or radiation therapy, and perhaps other factors that are currently unknown to us. Please click HERE to read more.