Clinical Trials

Major advances in medicine have been made by extending the biological discoveries in the laboratories to clinical settings and treating patients. This is the basic methodology that KRF is planning to use in finding better treatments for keloid disorder. This very important methodology will bring us unprecedented opportunities to change the practice of medicine, the obstacles facing us in treatment of patients with keloid. Medical research is a continuum that spans diverse realms of laboratory research and several kinds of clinical research. Clinical research is a crucial element and an essential step in this endeavor.

What is clinical research?

Clinical research refers to research conducted with human beings, including studies of specimens collected from patients who have keloid. It encompasses some laboratory research on the mechanisms of human disease, translational research (in which laboratory and clinical activities are closely aligned), clinical trials of preventive and therapeutic strategies, epidemiology, behavioral research, and health services and outcomes research.

Because it covers so many topics, clinical research the skills and expertise of many kinds of investigators, including physician scientists, public health, nursing and various laboratory sciences, are needed. Other professionals such as computer programmers, bio-engineers, and technicians are also essential for clinical research. Clinical research is conducted at a variety of sites and by a variety of entities. Academic Health Centers (AHCs), government labs and clinics, community hospitals, State health organizations, and managed care and pharmaceutical industry sites are all active participants in the Nation's clinical research enterprise. The success of clinical research depends on funding from both Federal and private sector sources. Much of the research funds are funneled to cancer research, and research in infectious diseases like HIV. With proper funding, KRF will be able to foster much needed research in keloid and pave the way for better understanding this disease and testing innovative treatments.

Clinical research has changed the face of modern medicine. At the end of World War II, physicians had little ability to effectively treat or prevent any of the deadliest diseases. Most of what we know as modem medicine, which we enjoy today were still unknown: antibiotics, vaccines for polio and several other severe infections, most hormone replacements and steroid therapy, effective drug therapies for cancer and psychotic illnesses, testing for genetic disorders, coronary bypass surgery, transplanted organs, and artificial joints. These and other successes have encouraged public enthusiasm for research and belief in the potency of modem medicine. Progress in cardio vascular disease, cancer, diabetes, infectious diseases, etc., would not have been possible without clinical research and funding that has supported the scientific discoveries. With similar enthusiasm, we can advance our understanding and treatments for keloid.

We do not even have statistics about keloid and do not know how prevalent this disease is. KRF intends to also develop a methodology to capture this data. We need to know how many people are suffering from this disease, so that we can effectively lobby for public and Federal research funds.

Medical research has visibly transformed the practice of medicine over the past fifty-sixty years, but even greater benefits may be possible in the future, if we are positioned to capitalize on the many profound developments that have recently occurred in fundamental science --- especially in genetics, structural biology, molecular and cell biology, computer science, and imaging technologies and applying all that to a keloid disorder, a disease that has been simply neglected by the research community.


    KRF Clinical Practice Guidelines for Treatment of Keloids:

    (January 11, 2019) KRF is proud to announce publication of several Keloid Treatment Guidelines. Authoring and production of these Guidelines has been a time-consuming task, yet one that has been long waited for. These Guidelines reflect the most up to date approach to treatment of keloids. We hope that the Guideline allow for establishment of standards in treating keloid patients across the globe. KRF Practice Guidelines.

    3rd International Keloid Symposium:

    (July 15, 2018) KRF is proud to announce that the 2nd was successfully held on June 7-8, 2018 in Rome, Italy with attendees from 22 different countries. During this meeting, KRF was invited to host the 3rd International Keloid Symposium in Beijing. Since the Rome meeting, the organizing committee has worked hard to make this a reality. We are now pleased to announce that our next meeting, the 3rd International Keloid Symposium, which will be a three day meeting will be held in Beijing, China on April 19-21 at the Lecture Hall of the Peking Union Medical College Hospital. Click on the image below to be directed to the symposium website.

    2nd International Keloid Symposium:

    (January 18, 2018) KRF is proudly announcing that the 2nd will be held on June 7-8, 2018 in Rome, Italy. Click on the image below to be directed to the symposium website.

    Notice of 501 (C)(3) Status:

    (February 1, 2017) Keloid Research Foundation has been determined by the US Internal Revenue Service (IRS) to be exempt from federal income tax under Internal Revenue Code (IRC) Section 501(C)(3). Donors can deduct contributions they make to KRF under IRC Section 170. Click here to view the 501(C)(3) Exemption Document.

    Journal of Keloid Research:

    (December 3, 2016)KRF is proud to announce establishment of Keloid Research, an open access scientific publication of the Keloid Research Foundation. Until now, keloid manuscripts have been published in a variety of journals. Our goal is to create a centralized publishing platform for all researchers who are passionate about this disorder, so that relevant clinical and laboratory research can be published in one place and under one umbrella. The journal is aiming to provide an international forum for the publication of original work, describing basic science, translational and clinical investigations in keloid disorder.

    Keloid Staging System:

    (August 19, 2016) In his most recent publication, "Neck Keloids: evaluation of risk factors and recommendation for keloid staging system" Dr. Tirgan has designed a staging system that allows for proper categorization and grouping of keloid patients into various stages.

    To assess each keloid patient properly, to better understand the natural history of this disorder, and to be able to compare future keloid study results among various patients groups, we clearly need a staging system that can allow us to describe the severity keloid disorder based on the size, location and/or extent of the keloidal lesions; as well as history of surgery or radiation therapy, and perhaps other factors that are currently unknown to us. Please click HERE to read more.